Transferability and Fine Mapping of Type 2 Diabetes Loci in African Americans: The Candidate Gene Association Resource Plus Study
نویسندگان
چکیده
Loci in African Americans The Candidate Gene Association Resource Plus Study Maggie C.Y. Ng, Richa Saxena, Jiang Li, Nicholette D. Palmer, Latchezar Dimitrov, Jianzhao Xu, Laura J. Rasmussen-Torvik, Joseph M. Zmuda, David S. Siscovick, Sanjay R. Patel, Errol D. Crook, Mario Sims, Yii-Der I. Chen, Alain G. Bertoni, Mingyao Li, Struan F.A. Grant, Josée Dupuis, James B. Meigs, Bruce M. Psaty, James S. Pankow, Carl D. Langefeld, Barry I. Freedman, Jerome I. Rotter, James G. Wilson, and Donald W. Bowden
منابع مشابه
Transferability and Fine Mapping of Type 2 Diabetes Loci in African Americans
Type 2 diabetes (T2D) disproportionally affects African Americans (AfA) but, to date, genetic variants identified from genome-wide association studies (GWAS) are primarily from European and Asian populations. We examined the single nucleotide polymorphism (SNP) and locus transferability of 40 reported T2D loci in six AfA GWAS consisting of 2,806 T2D case subjects with or without end-stage renal...
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Type 2 diabetes (T2D) is a complex metabolic disease that disproportionately affects African Americans. Genome-wide association studies (GWAS) have identified several loci that contribute to T2D in European Americans, but few studies have been performed in admixed populations. We first performed a GWAS of 1,563 African Americans from the Vanderbilt Genome-Electronic Records Project and Northwes...
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Genome wide association studies (GWAS) for type 2 diabetes (T2D) undertaken in European and Asian ancestry populations have yielded dozens of robustly associated loci. However, the genomics of T2D remains largely understudied in sub-Saharan Africa (SSA), where rates of T2D are increasing dramatically and where the environmental background is quite different than in these previous studies. Here,...
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Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of t...
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Type 2 diabetes (T2D) is a global health problem showing substantial ethnic disparity in disease prevalence. African Americans have one of the highest prevalence of T2D in the USA but little is known about their genetic risks. This review summarizes the findings of genetic regions and loci associated with T2D and related glycemic traits using linkage, admixture, and association approaches in po...
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